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Microgravity enables the development of advanced biological models, delivering novel insights about human health mechanisms and disease progression. The 3D spatial freedom allowed in microgravity aids in the self-assembly of cell types into complex tissue archetypes, creating organoid and other cell-based models that metabolically behave more closely to the human body. Additionally, microgravity affects cellular processes, accelerating maturation, and aging of models to provide models in a shorter timeframe than terrestrial development.